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Further, dihexa and Nle1-AngIV induce hippocampal spinogenesis and synaptogenesis similar to HGF itself

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doi:10.1016/j.lfs.2006.09.018 Canapp SO Jr, Farese JP, Schultz GS, et al

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These characteristics make them incompatible with the core requirements of GMP manufacturing, which mandate process controllability, robustness, scalability, and sterility assurance